Giant cell tumours (GCTs), also known as giant cell tumour of bone, are relatively rare tumours that typically occur in the bones. These tumours are usually benign, meaning they are non-cancerous, but in some cases, they can be locally aggressive and have the potential to recur.

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Giant cell tumours are characterized by the presence of a large number of multinucleated giant cells, as well as stromal cells. These tumours most commonly occur in the long bones, such as the distal femur (thigh bone) and the proximal tibia (shin bone), but they can also occur in other bones.

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Symptoms of giant cell tumours may include pain, swelling, and limited range of motion in the affected area. Treatment options for giant cell tumours may include surgery to remove the tumour, curettage (scraping out the tumour), and bone grafting. In some cases, additional treatments such as radiation therapy or targeted therapy may be used, especially if the tumour is aggressive or has a high risk of recurrence.